Ann Arbor is about 30 minutes by bus or car from Detroit Metro Airport (DTW), served by most major airlines. DTW is a Delta hub.
Frequent bus service from DTW to downtown Ann Arbor is provided by Michigan Flyer https://www.michiganflyer.com. It is about 10 minutes walk to campus from the bus depot
Amtrak routes from Chicago, Cleveland, etc. pass through Ann Arbor. The train station is about 1/2 mile from campus (up hill).
Ann Arbor is 3-4 hours by car from Fermilab.